The Enzyme mTOR as an Engine of Aging

Inhibiting mTOR, the “master determinant of lifespan,” is considered the best validated aging regulator.

So, how do you slow it down? This is the first video in a three-part series, so stay tuned for Inhibiting mTOR with Rapamycin for Extending Lifespan and Healthspan ( ) and Is Rapamycin a Universal Anti-Aging Drug? ( ).

For more on anti-aging, see:
• Dietary Sources of the “Longevity Vitamin” Ergothioneine ( )
• Greens, Green Tea, and Nuts Put to the Test for Telomeres ( )
• What to Eat to Prevent Telomere Shortening ( )
• The Best Diet for Healthy Aging ( )

And, for more on aging, check out my longevity book, How Not to Age ( ), available in print, e-book, and audio. (All proceeds I receive from the book are donated directly to charity.)

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Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at . You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics.

Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution!
-Michael Greger, MD FACLM

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Leroy Johnson
 

  • @Alexander-ok7fm says:

    Thank you!

  • @archangelarielle262 says:

    I just started for ME/ CFS. LDN already improved me from being very severe/ completely bedridden to 90% functional, however, that 10% is still quite debilitating. Plus, I hope it affects the pre-frontal cortex to aid ASD/ ADHD symptoms.

  • @ceresida says:

    Than you for your great work! I have to ask one thing about the mTOR — doesn’t mTOR do a bit different things in different human tissues? mTOR running the show in cancer cells is a disaster, however we wouldn’t have healthy, functional skeletal muscles without a bit of mTOR activation — isn’t it a question of balance and tradeoff?

  • @VeganLinked says:

    Meat, eggs, & dairy increase mTOR. Plant based diets decrease mTOR activity 🙂 So does fasting… A good balance may be ideal, so some mTOR activity for repair can be achieved through high protein whole plant foods like legumes and some nuts 💚🌱💚

    • @patrick-louisvincent4360 says:

      Why rich in protein? I’ve read that protein restriction prolongs healthy life (dr. MITCHELL)

    • @VeganLinked says:

      @@patrick-louisvincent4360 yes, protein restriction as in certain amino acids. And plant foods are lower in those particular amino acids and most are lower in protein and fat in general helping keep calories down which also reduces mTOR activity. But, you want “some” mTOR activity, hence my saying “A good balance may be ideal, so some mTOR activity for repair can be achieved through high protein whole plant foods like legumes and some nuts”

  • @christinetripp-g8p says:

    Fascinating!

  • @Perenbarn says:

    This man is a real science based educator. There are so many sham quacks out there pretending to be one… Niko Rittn— *cough*

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