ApoE—The Single Most Important Gene for Longevity
APOE is the primary cholesterol carrier in the brain and plays a major role in packaging and transporting LDL cholesterol throughout the body.
Is Longevity Genetic? ( ) was the previous video.
My new book, How Not to Age ( ), is all about aging and longevity, and you can get your copy now at your local public library or wherever books are sold. If you haven’t seen them yet, check out the book trailer ( ) and my new presentation ( ). (As always, all proceeds I receive from all of my books ( ) are donated to charity.)
New subscribers to our e-newsletter always receive a free gift. Get yours here: .
Have a question about this video? Leave it in the comment section at and someone on the NutritionFacts.org team will try to answer it.
Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at . You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics.
Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution!
-Michael Greger, MD FACLM
Captions for this video are available in several languages; you can find yours in the video settings. View important information about our translated resources:
• Subscribe:
• Donate:
• Podcast :
• Books:
• Shop:
• Facebook:
• Twitter:
• Instagram:
Another gene that may influence longevity: Many years ago I was diagnosed with Gilbert’s “disease.” But as it turns out, not only is it not considered to be a disease, but it increases a blood antioxidant, quite possibly extending life.
Oh yeah! It’s pretty cool. It’s actually quite popular for a “disease”. You can get jaundice when stressed but apart from that, it’s all benefits
Can you cite a source I can search on this matter ? Thanks !
Really? I have the same condition. Please share the study that you found this information. Thanks
Yes please! I’d love to learn more…my mothers family had it and I’m assuming I probably do as well (haven’t tested for it yet).
Stay up on the latest news by subscribing to NutritionFacts.org’s free e-newsletter and receive a handbook on the Anti-Aging Eight as a thank-you for subscribing. https://bit.ly/NF_newsletter. -NF Team
Fascinating! Thank you <3
If this is true, that would be a new hope for human ✌️👍.
This flies in the face of the BMJ study showing elderly people with higher LDL live longer than those with a lower level.
That’s interesting. Can you share that study, I’d like to read it.
@@DerekBarney search for the pdf “Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort”
@@DerekBarney I think with the BMJ study this is meant: ” Association between low density lipoprotein and all cause and cause specific mortality in Denmark: prospective cohort study:”
@@HvdHaghen The Denmark study said the lowest all cause mortality was an LDL of 140 mg/dL which in the USA would be considered high. Maybe that is why when Trump got his public 2018 health report he had an LDL of 143 mg/dL and he has never had any health problems. Like Dr. McDougall says it’s the food.
Reverse causation
Is there any advantage for having this gene?
Maybe people in Africa with low blood cholesterol evolved this gene so their brain can get a good supply of cholesterol. Just like how fat retention genes are gold when living in primal times with possible food scarcity. Now in time of abundance, these once beneficial genes have turned harmful
very interesting stuff, thank you Dr Greger, and to your team as well. 🙏
“May” be able to shuffle the deck through diet.
Considering that good diet also runs in families, eg Okinawans presumably have some similar genes, I’d be interested to know how they teased out the purely genetic effects
👍🏻👍🏻
Thank you for using the word “comprise” correctly.
I love this channel!
Peter Attia is all over this subject as well…….as this has been connected with Alzheimers and dementia………..
LOL!…just watched the video……..and see they cover this comment……..I will say though, its interesting about the Nigerians and if they come to this country they have better be careful that they don’t change their diets as then we are going to have a bunch of demented Nigerians over running our nursing homes…….I do like the fact that its shown if you have this type of DNA that diet avoids future problems, but I’m still a believer that if you have good genetics for longevity the chances are pretty good you will outlive someone who doesn’t regardless of your diet……..thats not to say if you have good genetics and you are abusive to your body you will still live to be ancient, but how many accounts of some of these people living to be 100 or more and they still drink and smoke and seem to be immnune to getting a chronic health issue from it………….
Attia doesn’t understand how diets work. Or, maybe, his financial ties to Virta make it impossible for him ))
Attia is fraud out to exploit ignorant people.
Kale Yeah!!
Thank you for this!
The story never changes… eat more plants.
Great video!
Interesting stuff; thanks Dr. Greger.
Interesting! If there’s one thing I’d like to avoid it’s Alzheimer’s…
Shockingly, my 93 yr old father has had a TERRIBLE diet his whole life. Heavy in meat & dairy, junk foods like chips & candy, and he’s still truckin’ along. It’s truly amazing.