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Podcast: The Anti-Aging Pathways of AMPK
Leroy Johnson
The concept is ridiculous on itself, Why would a hormone, a molecule thats only purpose is to message and control certain bodily mechanisms, in this case tissue growth, would prevent aging pathways? we age because our bodies are damaged from dna mutations, and as our bodys ability to create molecules and enzymes we actually need for maintaining our body slows down, our body also slows down the hormone production, especially hormones meant for cellular and tissue growth. Its like assuming your brain function will ultimately get better if you dump a lot of neurotransmitters into your brain. That is not how any of it works Im sure most are aware.
If there are no building blocks to build new tissue for, then the upper brass yelling at the workers ears will change nothing, it might fool the workers to do the job but at some point the exhaustion from lack of resources and food for the workers will make things worse.
Beacause it just might prevent sarcopenia, frailty and death….No IGF1, no stem cell activity(stem cell exhaustion). The Hallmarks of Aging ..The poison may be in the dose.
Growth = aging
Sorry your feelings got hurt..
@@D56t37-cu7ol aah but here lies the question my good sir, what causes this frailty, and if you ultimately induce your body to increase factors that prevent your body from being frail, what damage will you do? Its like a market bubble, we can artificially inflate the market but ultimately the bubble will pop, it will crash down, at the very least it will be unstable and slowly lose its stable ground, the metaphors point is that even if you fool your body into thinking it is not old, it is still old, the inefficiency and the damage gained over the course of multiple decades of radiation and mutagenic toxins damage do not disappear just because we induce certain functions in the biological system. Not that trt does not help with sarcopenia and in cases like in your 70s it might be preferable, I mean you are close to death relatively speaking so you might as well buy some extra functional years for it in terms of being able to stand on your own. But people in their 50s that start taking it after their middle age crises and then hope for a miracle tonic to fix the damage is the problem or even worse, the popularity of trt and hgh in people in their 30s and younger. Not to mention hgh has not been shown any benefit in muscle growth, so I do not understand where this craze even started, trt has clinically been proven at least to increase “virility” however badly you want to define that term.
Thank you for keeping me informed, Doc! 🥕🐇
Thank you for the information! 😊
2:41 – Did they end up taller?
Was more lumber required for their coffins?
@@leechurchill1965 I was just curious if it had the intended effect, apart from the side effects.
@@misterx3188 they usually use a combination of different growth hormones and thyroid hormones to more specifically target the platelets in your bones to grow, its unlikely that the kids saw any significant growth from this crude hgh treatment and if I remember correctly one of the original videos this podcast is a compilation of stated the study saw no growth benefit.
@@oskariKN25 Is there any way to actually see a growth benefit?
Cherry-picking. Only high-dose was associated with increased mortality, and only some types of cancer.
All-cause mortality was increased in treated subjects [standardized mortality ratio (SMR) 1.33, 95% confidence interval (CI) 1.08-1.64]. In a multivariate analysis adjusted for height, the use of GH doses greater than 50 μg/kg · d was associated with mortality rates using external and internal references (SMR 2.94, 95% CI 1.22-7.07, hazard ratio 2.79, 95% CI 1.14-6.82). All type cancer-related mortality was not increased. Bone tumor-related mortality was increased (SMR 5.00, 95% CI 1.01-14.63). An increase in mortality due to diseases of the circulatory system (SMR 3.07, 95% CI 1.40-5.83) or subarachnoid or intracerebral hemorrhage (SMR 6.66, 95% CI 1.79-17.05) was observed.
Why you call it cherry picking? The mortality rates you cite are all much higher than control
MTOR and IGF1 = vastly accelerated again. Aging doesn’t care about your cherry picked studies either
You can always tell the carnivores. Totally in denial. One study saying its true is one too many for me. I’ll be doing what Dr g suggests
@@Goodbyeeveryonehere I’m plant-based.
What about the dependency of the thymus on HGH, like the testes without gonadotropin the thymus surely shrinks… called “Thymic Involution” it’s a very real thing. It’s kind of sort of like (the same only different) as when your NO levels drop to zero around the age of 70, it contributes heavily to the accelerated aging and death between the ages of 70 and 80… When the curve starts to look like you’re about to go over Niagara Falls in a barrel… The thymus is an HGH dependent organ of the immune system ??? Maybe , the poison is in The Dose ??? Maybe if you get your exercise, diet, and supplements right your endogenous HGH won’t tumble so dramatically… Another scary thing is that after the age of 30 our dopamine levels drop 13% per decade, so by 70 we’re functioning on 50% …. and HGH levels are dopamine dependent … One of the hgh tests is an ldopa challenge test… Go figure, right ?
Thank you for the podcast info.
No wonder Joe Rogan looks like… OK, I won’t insult him.
I will. Big bloated bubble gut. Tomato red from high blood pressure. He is hard to look at. And even harder to listen to. The amount of misinformation he is responsible for is disgusting. A truly shameful human being.
You can’t fool Mother Nature!
Obviously using a single hormone is going to cause an imbalance, you can fool mother nature. We do it all the time, industrial fertilizers using synthetic nitrate compounds to stimulate growth, works wonders btw one of the reasons we have the luxury of eating whenever we please. In cell culture we use certain hormone cocktails to simulate bodily enviroments to make cells grow. If we had an ideal biomap we could simulate we could quite effectively “fool” the mysterious “mother nature”
Well said my friend.
Confirms what many of us have always suspected. If HGH reversed aging then bodybuilders would be models instead of bodybuilders lol
All bodybuilders look much older than they are.
I love these podcasts!
Had a friend take HGH, but a Dr would not give it too him so he got it in a gym. He had acid reflux before he started HGH. He was dead in a year from throat cancer. Don’t take HGH unless a “real” MD directs you to do so.
It’s simple, eat, low-fat and high carbohydrates and build elite level cardio and push yourself to absolute failure in the gym to build maximum health long-term, Carbs FTW!! 💪💪💪
What about the TRIIM trials that seem, according to the authors, reverse aging?
TRIIM trials were awesome.
Broski looks sick and malnourished