Risks and Benefits of Nicotinamide Mononucleotide (NMN), a NAD+ Booster
NR may just be a waste of money, safe but ineffective. NMN seems similarly useless in humans, but it may not even be safe.
This is the sixth video in my NAD+ series. Check out the previous ones:
• Do NAD+ Levels Decline with Age? ( )
• Can NAD+ Boosters Increase Lifespan and Healthspan? ( )
• Risks and Benefits of Nicotinic Acid (NA), a NAD+ Booster ( )
• Risks and Benefits of Nicotinamide (NAM), a NAD+ Booster ( )
• Risks and Benefits of Nicotinamide Riboside (NR), a NAD+ Booster ( )
Stay tuned for:
• Lesser-Known NAD+ Boosting Supplements—Tryptophan, NADH, NMNH, and NRH ( )
• Risks of NAD+ Boosting Supplements ( )
• Which NAD+ Booster Is Best? ( )
• The Third Way to Boost NAD+ ( )
For more on aging, go to your local public library and check out my longevity book, How Not to Age ( ), available in print, e-book, and audio. (All proceeds I receive from the book are donated directly to charity.)
New subscribers to our e-newsletter always receive a free gift. Get yours here: .
Have a question about this video? Leave it in the comment section at and someone on the NutritionFacts.org team will try to answer it.
Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at . You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics.
Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution!
-Michael Greger, MD FACLM
Captions for this video are available in several languages; you can find yours in the video settings. View important information about our translated resources:
• Subscribe:
• Donate:
• Podcast :
• Books:
• Shop:
• Facebook:
• Twitter:
• Instagram:
Gracias 🫂 por compartir tus videos 🙏
Saludos desde México ✌️😎
Muy interesante el estudio 😊
How do you choose your supplements at this point?
Lots of research, critical thinking, listening to different sources.
Audio is a little muffled.
Try after enabling stable volume in youtube(inside the gear icon)
I agree, could hardly workout what was being said…
Supplements suck.
That’s what he wants you do to believe.
@@CRM-114 Supplements are for losers who are eating the wrong food.
I love this channel!
Could you make a video on adaptogens please? Love your videos!
Thank you!
Can you make a video on supplements that actually work?
Creatine, omega3, vitamin d. Turmeric if you’re prediabetic. You’re welcome!
@@Kubaaano If these are the only ones in this industry, we are soooo scammed
For vegans: B12, Iodine (if you don’t eat seaweed), D3 with K2, Omega 3, Choline. Other good supplements that work: Tumeric, Amla, Ashwagandha, Ergothioneine.
there are no NMN supplements on Amazon, for about three years now. They have been banned, have no idea what he’s talking about there.
Thank David Sinclair for that.
Is it different than NMNH? Lots of those on Amazon
@@PositivelyDevine yeah it’s different, you can still get NMN on the internet through.
@@friedux2065 I look at lots of studies on NMN, it works great for me fat loss etc, but I’ve never heard the nerve thing that’s concerning, I understand you take these studies with a grain of salt but still!
@@forceof-nature2993 Dr. Greger is on an anti-supplement crusade. It’s cherry-picking. That’s why he doesn’t even recommend K2 (in combination with Vitamin D) or choline but these supplements would be very important for vegans. You need to look into other sources.
I always like to here where it can be found in natural whole plant food – it seems more abstract if it is just a supplement of some kind 🙏😊 ❤️
According to a 2023 study, this could, if at all, only affect people with compromised NMNAT activity, either caused by mutations, impaired axonal transport, or a decline in expression levels throughout life. Then it says in the study: “Realistically, NAD precursors are likely to be safe for most people.” I guess Dr. Greger “forgot” to mention this. And of course, the benefits and potentials of NMN (for example in the reversal of Alzheimer) aren’t mentioned anywhere. If he were interested in the truth, he would debate a scientist, an expert on the topic about this, instead of cherry-picking in his own echo chamber. We all know Dr. Greger hates supplements. He focuses on one tiny aspect that maybe, potentially, under certain circumstances could be a problem for some people and disregards everything else, thereby spreading fear. He did the same with resveratrol and in my opinion he completely misrepresented the resveratrol study.
Dude, there are no good studies establishing safety and efficacy of NAD+ precursors in humans. None. All scientists (other than Sinclair trying to push his nmn dang) in the longevity space agree that there’s no reason to take them.
Doesn’t mean they are bad, but it can easily be like resveratrol, a useless (and potentially harmful) supplement that for years was viewed as the holy grail of longevity (thanks again to that professional scammer Sinclair).
Ok, but David Sinclair showed that one mouse aged and another (on NMN) did not.
Sinclair obviously knows more about the subject.
@@BlueSkies360 Allegedly… and humans are not mice.
@@BlueSkies360 Very different lifespans and metabolisms.
Should do a vid on vapes and formaldehyde, they are more harm than good. A lot of youngsters are onto them because it’s cool, like the mmodern day cigarettes.
I think I’m over the NMN, NR & NAD+ suggestion, but I’m curious about how/if I’m exposed to it in ways that may be toxic. Since NMN is present in avocados, broccoli, etc, is that exposure potentially a problem? Not that a “yes” will make me stop eating those foods, but I want to know if its problem remains even with the lowest doses.
Is Tru Niagen’$ claims about telemere protection and restoration baseless? Is its only positive attribute that it is not harmful?
Cherry picking clinical studies is an art.
NMN unlike NR gives more energy and I don’t know why? Other people report the same too! So clearly it works differently
I would like to get your take on therapeutic peptides. The non animal product versions of them.